New Hope against viruses

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Common cold Virus (Wikipedia)

Microbiologists have reported that they have found a protein (SETD3) in humans that is essential to enable a wide range of viruses to replicate. That range includes the common cold, polio, cocksackie and viruses that cause paralysis and brain inflammation – these are all in the genus enteroviruses.

Currently we can try to counter these viruses with vaccines – very difficult when there are over a hundred different strains of common cold virus and the virus is continually evolving new strains. Or we may treat serious viral infections with anti-viral medications – but these are often expensive and the virus is free to evolve resistance to them. Thus this new discovery opens the possibility of taking a single medication that disables the human protein and stopping a large group of viruses in their tracks – they cannot evolve resistance because the medication is addressing the human protein, not one of their own. So the potential is very exciting.

However, the big question is whether disabling that human protein (albeit temporarily) would have deleterious effects on the human themself. A study in mice showed no ill-effects except that the mice had trouble giving birth because of interference with smooth muscle contraction. It is still possible the protein has other unidentified functions, and the exact method in which the virus uses the protein is still not clear, so there is much research still to be done.

Scientific American Article

Research Paper

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DRACOs – a novel antiviral

A novel broad-spectrum anti-viral

Dr. Todd Rider invented DRACOs (Double-stranded RNA Activated Caspase Oligomerizers) at MIT. DRACOs are novel broad-spectrum antiviral drugs that have the potential to revolutionize the treatment and prevention of virtually ALL viral diseases. So far, DRACOs have successfully treated 18 viruses in laboratory tests. DRACOs have proved effective against rhinovirus (the common cold), H1N1 influenza (flu), dengue hemorrhagic fever virus, and more. (This is a non-profit crowdfunding campaign.)

Explanatory Video

The basic mechanism is that double-stranded RNA only occurs within virally-infected cells, and it is only this type of RNA which activates the DRACO to trigger cell-death.

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